arthritis drug delivery methods

Different Ways to Take Arthritis Medications

Your doctor can prescribe a variety of medicines to treat your arthritis and its symptoms. Here’s a look at drug delivery methods for different arthritis medications.


Oral Medicines

Many of the drugs you take for arthritis – including acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), some disease-modifying antirheumatic drugs (DMARDs) and corticosteroids – come in pill form. Instructions vary, but typically you’ll swallow the pill(s) with a big sip of water.

The label might also specify that you take your medicine on a full stomach, but it may matter what you eat or drink. Once your body digests the pill, its contents will be absorbed into your bloodstream and take effect.

Talk to your doctor before trying to cut, crush or chew your pills. While some DMARDs may be taken as a divided dose, there are others that must be swallowed whole. If you have trouble swallowing pills, some medications are available as liquids.

Topical Medicines

Topicals deliver medicines through your skin. NSAIDs, salicylates and capsaicin are available as creams or gels that you rub on your skin. Opioid medicines, NSAIDs and lidocaine are available in as a patch you apply to the skin. A patch delivers a steady dose of medicine into your bloodstream over several hours. You will leave it on for 12 or more hours, depending on the drug, and then remove it. If you have psoriatic arthritis or another skin condition, talk to your doctor before using a topical medicine.


Some people take the DMARD methotrexate as an injection because it may be more effective that way. Several biologic drugs (a subset of DMARDs) have to be injected because there are no pill forms available. While it can be scary to think about using a needle on yourself, your doctor or nurse will show you how to prepare and inject the drug. You should get the hang of it fairly quickly. If you’d prefer not to do it yourself, ask a friend or family member to learn how and give you the injections.

Injectables come two ways depending on the drug: with an auto-injector pen or a syringe. Some injectables need refrigeration. If you travel often for work or pleasure, you’ll need to plan ahead to have access to a fridge.

The needle is shorter than the ones you’re used to getting at your doctor’s office. You’ll place the needle into an area of fat between the skin and muscle, called the subcutaneous layer. The best places to give yourself an injection are in the side of your thigh or the bottom part of your stomach (a few inches away from your bellybutton). If someone is helping you, they can give you the injection in the back of your arm. Don’t use the same spot each time you inject to prevent soreness. You can rub an ice cube on your skin first to numb the region. Then, clean the area with an alcohol swab.

With the auto-injector, the medicine is already inside the pen. You simply take off the cap and hold the device firmly against your skin. Then you press and hold the button on the pen, and the needle injects the medicine into your subcutaneous layer.

Syringes may be either prefilled or empty. You’ll have to fill the empty ones yourself from a multi-use vial. You pinch your skin with a bit of fat, quickly insert the needle, and push down the plunger to inject the medicine.

Once you’re done injecting with either an auto-injector or syringe, dispose of the needle in a special container you get from the pharmacy. After the injection, some people develop a skin reaction at the site of the needle puncture. Injection-site reactions cause symptoms like redness, itching, pain and possibly a rash. If you see these symptoms, call your doctor.


Several of the biologic drugs need to go straight into your bloodstream to be effective. You’ll get these drugs as an infusion, which is through a needle placed into a vein (called an IV). You’ll visit the doctor’s office, a hospital or an infusion center to get the drug. Infusions are given on different schedules, ranging from weeks to months apart. You may need to take time off work and plan around your travel schedule to get your infusions.

About 30 minutes before your infusion, you may get a corticosteroid medicine through a vein to prevent you from having a reaction to the infusion drug. While you get the infusion, the nurses will check your breathing rate and blood pressure and monitor for signs of a reaction to the biologic. If you do have a reaction, your doctor will give you an antihistamine, acetaminophen, or a steroid drug to treat it.

Wear loose-fitting clothing during your infusion to make it easier for the medical team to monitor your vital signs, and to keep you more comfortable while you wait. Bring a book or music player. Some infusions can take two hours or longer. You will need to watch for signs of an infusion or injection-site reaction at home, because some reactions can occur up to 14 days after treatment. Signs of an infusion reaction include flushing, rash, fever, headache, shortness of breath, chest pain and heart palpitations. Call your doctor if you have signs of an infusion reaction.

The Arthritis Foundation is the leading organization 
providing support and funding research to improve the 
lives of individuals with arthritis. You can help!